Prescribing Information
Important Safety Information
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Navigator Program: Patient Support by Orphalan

The Navigator Program is a no cost program available to you that was created to provide access support throughout your entire treatment journey with CUVRIORTM (trientine tetrahydrochloride)

From start to finish, you can rely on your dedicated Care Coordinator to be there for you and to help you:

  • Get started on therapy while the pharmacy and your healthcare professional work with your insurance plan to obtain ongoing coverage
  • Understand your insurance coverage for CUVRIOR
  • Understand the processes required by your insurance to access CUVRIOR (such as Prior Authorizations)
  • Provide you with information related to Co Pay and/or financial assistance programs that may be available to you
Have questions about how the Navigator Program can support you throughout your treatment journey?
Contact a Care Coordinator today to learn more: 1-877-995-ORPH (6774)
Offerings available through the Navigator Program include the following:
Getting started on a specialty medication can be challenging. Your dedicated Care Coordinator is trained to help you navigate this process, providing you with education and support about how to access your medication!

For more information, contact the Navigator Program by calling 1-877-995-ORPH (6774)!
Experiencing insurance-related delays? The Navigator Program may be able to help you get started on treatment while you wait!

Contact your Care Coordinator today on 1-877-995-ORPH (6774) to see if you qualify!

*Enrollment required. Terms and conditions apply.
Eligible patients may pay as little as $0 per month for CUVRIOR!

Commercially insured patients with a valid prescription for CUVRIOR may be eligible to participate in the Orphalan Co Pay Program.

To learn more about this offering and find out if you qualify, call 1-877-995-ORPH (6774) to speak with a Care Coordinator today!

*Terms and conditions apply.
Uninsured? No coverage for CUVRIOR through your insurance? Financial concerns related to high out-of-pocket expenses?

The Orphalan Patient Assistance Program may be able to help!

Contact a Care Coordinator on 1-877-995-ORPH (6774) to learn more about this program and see if it may be right for you!

*Enrollment and financial assessment required. Terms and conditions apply.

Indication & Important Safety Information

CUVRIOR is a prescription medicine for the treatment of adult patients with stable Wilson Disease who are de-coppered and able to take penicillamine. CUVRIOR is a chelating medicine which binds copper, helping your organs release copper into your bloodstream which is then removed through your urine.
Important Safety Information
INDICATION
CUVRIOR is a copper chelator indicated for the treatment of adult patients with stable Wilson Disease who are de-coppered and tolerant to penicillamine.
IMPORTANT SAFETY INFORMATION
  • Do not use CUVRIOR if you are allergic to trientine or to any of the ingredients in CUVRIOR.
  • Your Wilson’s Disease symptoms could get worse when you start treatment. This could happen because too much copper is removed from the body in a short period of time. Your doctor may need to reduce your dose or stop CUVRIOR treatment.
  • Copper deficiency may develop following treatment with CUVRIOR. Your doctor will do tests to monitor your urine and blood for copper.
  • Iron deficiency may develop while taking CUVRIOR. If this happens, your doctor may tell you to take iron supplements for a limited time.
  • Allergic reactions, such as a rash, have been reported with trientine, the active ingredient in CUVRIOR. If a rash or other allergic reaction occurs, stop taking CUVRIOR and get emergency medical help.
  • The most common side effects are pain in the abdomen, change in bowel habits, rash, hair loss (alopecia), and mood swings.

Take CUVRIOR at least 1 hour apart from any other oral medicine. Tell your doctor about all the medicines you're taking, including over-the-counter medicines, vitamins, and herbal supplements. Avoid taking supplements when taking CUVRIOR. Taking CUVRIOR with mineral supplements (e.g., iron, zinc, calcium, magnesium) can reduce the effectiveness of CUVRIOR. If iron supplementation is necessary, take CUVRIOR at least 2 hours before or 2 hours after taking iron; for other mineral supplements (e.g., zinc, calcium, magnesium), take CUVRIOR at least 1 hour before or 2 hours after. Do not start or stop any medicines while taking CUVRIOR without talking to your doctor.

These are not all the possible side effects of CUVRIOR. You are encouraged to report negative side effects of prescription drugs. Contact Orphalan at 1-800-961-8320 or AdverseEventReporting@orphalan.com or FDA at 1-800-FDA-1088 or www.fda.gov/​medwatch.

Please see full Prescribing Information.